The GATA1-HS2 Enhancer Allows Persistent and Position-Independent Expression of a β-globin Transgene

Gene therapy of genetic diseases requires persistent and position-independent expression of a therapeutic transgene. Transcriptional enhancers binding chromatin-remodeling and modifying complexes may play a role in shielding transgenes from repressive chromatin effects. We tested the activity of the...

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Autors principals: Miccio, Annarita, Poletti, Valentina, Tiboni, Francesca, Rossi, Claudia, Antonelli, Antonella, Mavilio, Fulvio, Ferrari, Giuliana
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2011
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3229501/
https://ncbi.nlm.nih.gov/pubmed/22164220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0027955
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