Structural Elements in the Gα(s) and Gα(q) C Termini That Mediate Selective G Protein-coupled Receptor (GPCR) Signaling

Although the importance of the C terminus of the α subunit of the heterotrimeric G protein in G protein-coupled receptor (GPCR)-G protein pairing is well established, the structural basis of selective interactions remains unknown. Here, we combine live cell FRET-based measurements and molecular dyna...

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Détails bibliographiques
Publié dans:J Biol Chem
Auteurs principaux: Semack, Ansley, Sandhu, Manbir, Malik, Rabia U., Vaidehi, Nagarajan, Sivaramakrishnan, Sivaraj
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2016
Sujets:
Signal Transduction
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5016181/
https://ncbi.nlm.nih.gov/pubmed/27330078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.735720
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