Synergistic Ca(2+) Responses by Gα(i)- and Gα(q)-coupled G-protein-coupled Receptors Require a Single PLCβ Isoform That Is Sensitive to Both Gβγ and Gα(q)

Cross-talk between Gα(i)- and Gα(q)-linked G-protein-coupled receptors yields synergistic Ca(2+) responses in a variety of cell types. Prior studies have shown that synergistic Ca(2+) responses from macrophage G-protein-coupled receptors are primarily dependent on phospholipase Cβ3 (PLCβ3), with a p...

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Autori principali: Rebres, Robert A., Roach, Tamara I. A., Fraser, Iain D. C., Philip, Finly, Moon, Christina, Lin, Keng-Mean, Liu, Jamie, Santat, Leah, Cheadle, Lucas, Ross, Elliott M., Simon, Melvin I., Seaman, William E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2011
Soggetti:
Signal Transduction
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3020779/
https://ncbi.nlm.nih.gov/pubmed/21036901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.198200
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