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Synergistic Activation of Phospholipase C-β3 by Gα(q) and Gβγ Describes a Simple Two-State Coincidence Detector
BACKGROUND: Receptors that couple to G(i) and G(q) often interact synergistically in cells to elicit cytosolic Ca(2+) transients that are several-fold higher than the sum of those driven by each receptor alone. Such synergism is commonly assumed to be complex, requiring regulatory interaction betwee...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2918712/ https://ncbi.nlm.nih.gov/pubmed/20579885 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2010.06.013 |
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