Gβγ signaling to the chemotactic effector P-REX1 and mammalian cell migration is directly regulated by Gα(q) and Gα(13) proteins

G protein–coupled receptors stimulate Rho guanine nucleotide exchange factors that promote mammalian cell migration. Rac and Rho GTPases exert opposing effects on cell morphology and are stimulated downstream of Gβγ and Gα(12/13) or Gα(q), respectively. These Gα subunits might in turn favor Rho path...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Biol Chem
Auteurs principaux: Cervantes-Villagrana, Rodolfo Daniel, Adame-García, Sendi Rafael, García-Jiménez, Irving, Color-Aparicio, Víctor Manuel, Beltrán-Navarro, Yarely Mabell, König, Gabriele M., Kostenis, Evi, Reyes-Cruz, Guadalupe, Gutkind, J. Silvio, Vázquez-Prado, José
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2019
Sujets:
Signal Transduction
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6333895/
https://ncbi.nlm.nih.gov/pubmed/30446620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.006254
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