A Novel Interaction of the Catalytic Subunit of Protein Phosphatase 2A with the Adaptor Protein CIN85 Suppresses Phosphatase Activity and Facilitates Platelet Outside-in α(IIb)β(3) Integrin Signaling

The transduction of signals generated by protein kinases and phosphatases are critical for the ability of integrin α(IIb)β(3) to support stable platelet adhesion and thrombus formation. Unlike kinases, it remains unclear how serine/threonine phosphatases engage the signaling networks that are initia...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Main Authors: Khatlani, Tanvir, Pradhan, Subhashree, Da, Qi, Shaw, Tanner, Buchman, Vladimir L., Cruz, Miguel A., Vijayan, K. Vinod
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Signal Transduction
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5016133/
https://ncbi.nlm.nih.gov/pubmed/27334924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.704296
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