The heterotrimeric G protein Gβ(1) interacts with the catalytic subunit of protein phosphatase 1 and modulates G protein–coupled receptor signaling in platelets

Thrombosis is caused by the activation of platelets at the site of ruptured atherosclerotic plaques. This activation involves engagement of G protein–coupled receptors (GPCR) on platelets that promote their aggregation. Although it is known that protein kinases and phosphatases modulate GPCR signali...

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Pradhan, Subhashree, Khatlani, Tanvir, Nairn, Angus C., Vijayan, K. Vinod
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2017
Schlagworte:
Signal Transduction
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5555177/
https://ncbi.nlm.nih.gov/pubmed/28615442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.796656
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