The β isoform of the catalytic subunit of protein phosphatase 2B restrains platelet function by suppressing outside-in αIIbβ3 integrin signaling

BACKGROUND: Calcium dependent signaling mechanisms play a critical role in platelet activation. Unlike calcium-activated protease and kinase, the contribution of calcium-activated protein serine/threonine phosphatase in platelet activation is poorly understood. OBJECTIVE: To assess the role of catal...

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Detalhes bibliográficos
Publicado no:J Thromb Haemost
Main Authors: Khatlani, Tanvir, Pradhan, Subhashree, Da, Qi, Gushiken, Francisca C., Bergeron, Angela L., Langlois, Kimberly W., Molkentin, Jeffery D., Rumbaut, Rolando E., Vijayan, K. Vinod
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4268338/
https://ncbi.nlm.nih.gov/pubmed/25330904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jth.12761
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