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The Structural Basis for Cdc42-induced Dimerization of IQGAPs
In signaling, Rho-family GTPases bind effector proteins and alter their behavior. Here we present the crystal structure of Cdc42•GTP bound to the GTPase-activating protein (GAP)-related domain (GRD) of IQGAP2. Four molecules of Cdc42 are bound to two GRD molecules, which bind each other in a paralle...
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| Publicado en: | Structure |
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| Autores principales: | , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2016
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5014685/ https://ncbi.nlm.nih.gov/pubmed/27524202 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2016.06.016 |
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