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The IQGAP1 N-terminus Forms Dimers and the Dimer Interface is Required for Binding F-actin and Ca(2+)/calmodulin
IQGAP1 is a multi-domain scaffold protein involved in many cellular processes. We have determined the crystal structure of an N-terminal fragment spanning residues 1-191 (CHDF hereafter) which contains the entire calponin homology domain. The structure of the CHDF is very similar to other Type 3 cal...
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| Publicado no: | Biochemistry |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5543714/ https://ncbi.nlm.nih.gov/pubmed/27798963 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b00745 |
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