Crystal Structure of the GTPase-activating Protein-related Domain from IQGAP1

IQGAP1 is a 190-kDa molecular scaffold containing several domains required for interaction with numerous proteins. One domain is homologous to Ras GTPase-activating protein (GAP) domains. However, instead of accelerating hydrolysis of bound GTP on Ras IQGAP1, using its GAP-related domain (GRD) binds...

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Bibliographic Details
Main Authors: Kurella, Vinodh B., Richard, Jessica M., Parke, Courtney L., LeCour, Louis F., Bellamy, Henry D., Worthylake, David K.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2009
Subjects:
Mechanisms of Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2685667/
https://ncbi.nlm.nih.gov/pubmed/19321438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M808974200
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