Ubiquitination of the scaffold protein IQGAP1 diminishes its interaction with and activation of the Rho GTPase CDC42

IQ motif-containing GTPase-activating protein 1 (IQGAP1) is a scaffold protein that interacts with numerous binding partners and thereby regulates fundamental biological processes. The functions of IQGAP1 are modulated by several mechanisms, including protein binding, self-association, subcellular l...

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Pubblicato in:J Biol Chem
Autori principali: Gorisse, Laëtitia, Li, Zhigang, Wagner, Craig D., Worthylake, David K., Zappacosta, Francesca, Hedman, Andrew C., Annan, Roland S., Sacks, David B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2020
Soggetti:
Signal Transduction
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7152761/
https://ncbi.nlm.nih.gov/pubmed/32094223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.011491
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