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Structural Basis for Ca(2+)-induced Activation and Dimerization of Estrogen Receptor α by Calmodulin
The estrogen receptor α (ER-α) regulates expression of target genes implicated in development, metabolism, and breast cancer. Calcium-dependent regulation of ER-α is critical for activating gene expression and is controlled by calmodulin (CaM). Here, we present the NMR structures for the two lobes o...
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| Main Authors: | , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society for Biochemistry and Molecular Biology
2012
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3308758/ https://ncbi.nlm.nih.gov/pubmed/22275375 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.334797 |
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