Structural Basis for Ca(2+)-induced Activation and Dimerization of Estrogen Receptor α by Calmodulin

The estrogen receptor α (ER-α) regulates expression of target genes implicated in development, metabolism, and breast cancer. Calcium-dependent regulation of ER-α is critical for activating gene expression and is controlled by calmodulin (CaM). Here, we present the NMR structures for the two lobes o...

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Hlavní autoři: Zhang, Yonghong, Li, Zhigang, Sacks, David B., Ames, James B.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2012
Témata:
Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3308758/
https://ncbi.nlm.nih.gov/pubmed/22275375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.334797
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