Calmodulin Lobes Facilitate Dimerization and Activation of Estrogen Receptor-α

Estrogen receptor α (ER-α) is a nuclear hormone receptor that controls selected genes, thereby regulating proliferation and differentiation of target tissues, such as breast. Gene expression controlled by ER-α is modulated by Ca(2+) via calmodulin (CaM). Here we present the NMR structure of Ca(2+)-C...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Li, Zhigang, Zhang, Yonghong, Hedman, Andrew C., Ames, James B., Sacks, David B.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2017
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5377777/
https://ncbi.nlm.nih.gov/pubmed/28174300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.754804
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