The Structural Basis for Cdc42-induced Dimerization of IQGAPs

In signaling, Rho-family GTPases bind effector proteins and alter their behavior. Here we present the crystal structure of Cdc42•GTP bound to the GTPase-activating protein (GAP)-related domain (GRD) of IQGAP2. Four molecules of Cdc42 are bound to two GRD molecules, which bind each other in a paralle...

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Bibliografiska uppgifter
I publikationen:Structure
Huvudupphovsmän: LeCour, Louis, Boyapati, Vamsi. K., Liu, Jing, Li, Zhigang, Sacks, David B., Worthylake, David K.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2016
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5014685/
https://ncbi.nlm.nih.gov/pubmed/27524202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2016.06.016
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