Bayesian Two-stage Biomarker-based Adaptive Design for Targeted Therapy Development

We propose a Bayesian two-stage biomarker-based adaptive randomization (AR) design for the development of targeted agents. The design has three main goals: (1) to test the treatment efficacy, (2) to identify prognostic and predictive markers for the targeted agents, and (3) to provide better treatme...

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Pubblicato in:Stat Biosci
Autori principali: Gu, Xuemin, Chen, Nan, Wei, Caimiao, Liu, Suyu, Papadimitrakopoulou, Vassiliki A., Herbst, Roy S., Lee, J. Jack
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5014437/
https://ncbi.nlm.nih.gov/pubmed/27617040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12561-014-9124-2
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