JUN dependency in distinct early and late BRAF inhibition adaptation states of melanoma

A prominent mechanism of acquired resistance to BRAF inhibitors in BRAF(V600)-mutant melanoma is associated with the upregulation of receptor tyrosine kinases. Evidences suggested that this resistance mechanism is part of a more complex cellular adaptation process. Using an integrative strategy, we...

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Udgivet i:Cell Discov
Main Authors: Titz, Bjoern, Lomova, Anastasia, Le, Allison, Hugo, Willy, Kong, Xiangju, ten Hoeve, Johanna, Friedman, Michael, Shi, Hubing, Moriceau, Gatien, Song, Chunying, Hong, Aayoung, Atefi, Mohammad, Li, Richard, Komisopoulou, Evangelia, Ribas, Antoni, Lo, Roger S, Graeber, Thomas G
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5012007/
https://ncbi.nlm.nih.gov/pubmed/27648299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/celldisc.2016.28
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