Acquired resistance and clonal evolution in melanoma during BRAF inhibitor therapy

BRAF inhibitors elicit rapid anti-tumor responses in the majority of patients with (V600)BRAF mutant melanoma, but acquired drug resistance is almost universal. We sought to identify the core resistance pathways and the extent of tumor heterogeneity during disease progression. We show that MAPK reac...

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Detalhes bibliográficos
Main Authors: Shi, Hubing, Hugo, Willy, Kong, Xiangju, Hong, Aayoung, Koya, Richard C., Moriceau, Gatien, Chodon, Thinle, Guo, Rongqing, Johnson, Douglas B., Dahlman, Kimberly B., Kelley, Mark C., Kefford, Richard F., Chmielowski, Bartosz, Glaspy, John A., Sosman, Jeffrey A., van Baren, Nicolas, Long, Georgina V., Ribas, Antoni, Lo, Roger S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3936420/
https://ncbi.nlm.nih.gov/pubmed/24265155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-13-0642
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