A novel AKT1 mutant amplifies an adaptive melanoma response to BRAF inhibition

BRAF inhibitor (BRAFi) therapy leads to remarkable anti-melanoma responses, but the initial tumor shrinkage is commonly incomplete, providing a nidus for subsequent disease progression. Adaptive signaling may underlie early BRAFi resistance and influence the selection pattern for genetic variants ca...

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Autori principali: Shi, Hubing, Hong, Aayoung, Kong, Xiangju, Koya, Richard C., Song, Chunying, Moriceau, Gatien, Hugo, Willy, Yu, Clarissa C., Ng, Charles, Chodon, Thinle, Scolyer, Richard A., Kefford, Richard F., Ribas, Antoni, Long, Georgina V., Lo, Roger S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3893054/
https://ncbi.nlm.nih.gov/pubmed/24265152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-13-0279
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