Non-genomic and Immune Evolution of Melanoma Acquiring MAPKi Resistance

Clinically acquired resistance to MAPK inhibitor (MAPKi) therapies for melanoma cannot be fully explained by genomic mechanisms and may be accompanied by co-evolution of intra-tumoral immunity. We sought to discover non-genomic mechanisms of acquired resistance and dynamic immune compositions by a c...

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Detalhes bibliográficos
Publicado no:Cell
Main Authors: Hugo, Willy, Shi, Hubing, Sun, Lu, Piva, Marco, Song, ChunYing, Kong, Xiangju, Moriceau, Gatien, Hong, Aayoung, Dahlman, Kimberly B., Johnson, Douglas B., Sosman, Jeffrey A., Ribas, Antoni, Lo, Roger S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4821508/
https://ncbi.nlm.nih.gov/pubmed/26359985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.07.061
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