First comprehensive structural and biophysical analysis of MAPK13 inhibitors targeting DFG-in and DFG-out binding modes

BACKGROUND: P38 MAP kinases are centrally involved in mediating extracellular signaling in various diseases. While much attention has previously been focused on the ubiquitously expressed family member MAPK14 (p38α), recent studies indicate that family members such as MAPK13 (p38δ) display a more se...

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Detalhes bibliográficos
Publicado no:Biochim Biophys Acta
Main Authors: Yurtsever, Zeynep, Patel, Dhara A., Kober, Daniel L., Su, Alvin, Miller, Chantel A., Romero, Arthur G., Holtzman, Michael J., Brett, Tom J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5011001/
https://ncbi.nlm.nih.gov/pubmed/27369736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbagen.2016.06.023
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