TREM2-ligand interactions in health and disease

Por Kober, Daniel L., Brett, Tom J.
Publicado no J Mol Biol (2017)

Efficient Mammalian Cell Expression and Single-step Purification of Extracellular Glycoproteins for Crystallization

Por Kober, Daniel L., Yurtsever, Zeynep, Brett, Thomas J.
Publicado no J Vis Exp (2015)

Preparation, Crystallization, and Preliminary Crystallographic Analysis of Wild-type and Mutant Human TREM-2 Ectodomains Linked to Neurodegenerative and Inflammatory Diseases

Por Kober, Daniel L., Wanhainen, Kelsey M., Johnson, Britney M., Randolph, David T., Holtzman, Michael J., Brett, Tom J.
Publicado em 2014

Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms

Por Kober, Daniel L, Alexander-Brett, Jennifer M, Karch, Celeste M, Cruchaga, Carlos, Colonna, Marco, Holtzman, Michael J, Brett, Thomas J
Publicado no eLife (2016)

First comprehensive structural and biophysical analysis of MAPK13 inhibitors targeting DFG-in and DFG-out binding modes

Por Yurtsever, Zeynep, Patel, Dhara A., Kober, Daniel L., Su, Alvin, Miller, Chantel A., Romero, Arthur G., Holtzman, Michael J., Brett, Tom J.
Publicado no Biochim Biophys Acta (2016)

TREM-2 promotes macrophage survival and lung disease after respiratory viral infection

Por Wu, Kangyun, Byers, Derek E., Jin, Xiaohua, Agapov, Eugene, Alexander-Brett, Jennifer, Patel, Anand C., Cella, Marina, Gilfilan, Susan, Colonna, Marco, Kober, Daniel L., Brett, Tom J., Holtzman, Michael J.
Publicado no J Exp Med (2015)

Microfibril-associated Glycoprotein 2 (MAGP2) Loss of Function Has Pleiotropic Effects in Vivo

Por Combs, Michelle D., Knutsen, Russell H., Broekelmann, Thomas J., Toennies, Holly M., Brett, Thomas J., Miller, Chantel A., Kober, Daniel L., Craft, Clarissa S., Atkinson, Jeffrey J., Shipley, J. Michael, Trask, Barbara C., Mecham, Robert P.
Publicado em 2013