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Structural Elucidation of the DFG-Asp in and DFG-Asp out States of TAM Kinases and Insight into the Selectivity of Their Inhibitors

Structural elucidation of the active (DFG-Asp in) and inactive (DFG-Asp out) states of the TAM family of receptor tyrosine kinases is required for future development of TAM inhibitors as drugs. Herein we report a computational study on each of the three TAM members Tyro-3, Axl and Mer. DFG-Asp in an...

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Hlavní autoři: Abdellah Messoussi, Lucile Peyronnet, Clémence Feneyrolles, Gwénaël Chevé, Khalid Bougrin, Aziz Yasri
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI AG 2014-10-01
Edice:Molecules
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On-line přístup:http://www.mdpi.com/1420-3049/19/10/16223
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