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Determination and validation of mTOR kinase-domain 3D structure by homology modeling
The AKT/mammalian target of rapamycin (mTOR) pathway is considered as one of the commonly activated and deregulated signaling pathways in human cancer. mTOR is associated with other proteins in two molecular complexes: mTOR complex 1/Raptor and the mTOR complex 2/Rictor. Using the crystal structure...
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| Udgivet i: | Onco Targets Ther |
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| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Dove Medical Press
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4525790/ https://ncbi.nlm.nih.gov/pubmed/26257525 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/OTT.S84200 |
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