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Determination and validation of mTOR kinase-domain 3D structure by homology modeling
The AKT/mammalian target of rapamycin (mTOR) pathway is considered as one of the commonly activated and deregulated signaling pathways in human cancer. mTOR is associated with other proteins in two molecular complexes: mTOR complex 1/Raptor and the mTOR complex 2/Rictor. Using the crystal structure...
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| Veröffentlicht in: | Onco Targets Ther |
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| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Dove Medical Press
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4525790/ https://ncbi.nlm.nih.gov/pubmed/26257525 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/OTT.S84200 |
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