Structural Elucidation of the DFG-Asp in and DFG-Asp out States of TAM Kinases and Insight into the Selectivity of Their Inhibitors

Structural elucidation of the active (DFG-Asp in) and inactive (DFG-Asp out) states of the TAM family of receptor tyrosine kinases is required for future development of TAM inhibitors as drugs. Herein we report a computational study on each of the three TAM members Tyro-3, Axl and Mer. DFG-Asp in an...

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Detalhes bibliográficos
Publicado no:Molecules
Main Authors: Messoussi, Abdellah, Peyronnet, Lucile, Feneyrolles, Clémence, Chevé, Gwénaël, Bougrin, Khalid, Yasri, Aziz
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6271404/
https://ncbi.nlm.nih.gov/pubmed/25310149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules191016223
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