ST-11: a new brain-penetrant microtubule-destabilizing agent with therapeutic potential for glioblastoma multiforme

Glioblastoma multiforme (GBM) is a devastating and intractable type of cancer. Current antineoplastic drugs do not improve the median survival of patients diagnosed with GBM beyond 14–15 months in part because the blood-brain barrier is generally impermeable to many therapeutic agents. Drugs that ta...

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Publicat a:Mol Cancer Ther
Autors principals: Cherry, Allison E., Haas, Brian R., Naydenov, Alipi V., Fung, Susan, Xu, Cong, Swinney, Katie, Wagenbach, Michael, Freeling, Jennifer, Canton, David A., Coy, Jonathan, Horne, Eric A., Rickman, Barry, Vicente, Juan Jesus, Scott, John D., Ho, Rodney J. Y., Liggitt, Denny, Wordeman, Linda, Stella, Nephi
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5010991/
https://ncbi.nlm.nih.gov/pubmed/27325686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-15-0800
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