Modified carbazoles destabilize microtubules and kill glioblastoma multiform cells

Small molecules that target microtubules (MTs) represent promising therapeutics to treat certain types of cancer, including glioblastoma multiform (GBM). We synthesized modified carbazoles and evaluated their antitumor activity in GBM cells in culture. Modified carbazoles with an ethyl moiety linked...

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Detalhes bibliográficos
Publicado no:Eur J Med Chem
Main Authors: Diaz, Philippe, Horne, Eric, Xu, Cong, Hamel, Ernest, Wagenbach, Michael, Petrov, Ravil R., Uhlenbruck, Benjamin, Haas, Brian, Hothi, Parvinder, Wordeman, Linda, Gussio, Rick, Stella, Nephi
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6690746/
https://ncbi.nlm.nih.gov/pubmed/30268825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2018.09.026
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