ST-11: a new brain-penetrant microtubule-destabilizing agent with therapeutic potential for glioblastoma multiforme

Glioblastoma multiforme (GBM) is a devastating and intractable type of cancer. Current antineoplastic drugs do not improve the median survival of patients diagnosed with GBM beyond 14–15 months in part because the blood-brain barrier is generally impermeable to many therapeutic agents. Drugs that ta...

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Detalhes bibliográficos
Publicado no:Mol Cancer Ther
Main Authors: Cherry, Allison E., Haas, Brian R., Naydenov, Alipi V., Fung, Susan, Xu, Cong, Swinney, Katie, Wagenbach, Michael, Freeling, Jennifer, Canton, David A., Coy, Jonathan, Horne, Eric A., Rickman, Barry, Vicente, Juan Jesus, Scott, John D., Ho, Rodney J. Y., Liggitt, Denny, Wordeman, Linda, Stella, Nephi
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5010991/
https://ncbi.nlm.nih.gov/pubmed/27325686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-15-0800
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