A brain-penetrant microtubule-targeting agent that disrupts hallmarks of glioma tumorigenesis

BACKGROUND: Glioma is sensitive to microtubule-targeting agents (MTAs), but most MTAs do not cross the blood brain barrier (BBB). To address this limitation, we developed the new chemical entity, ST-401, a brain-penetrant MTA. METHODS: Synthesis of ST-401. Measures of MT assembly and dynamics. Cell...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Neurooncol Adv
Main Authors: Horne, Eric A, Diaz, Philippe, Cimino, Patrick J, Jung, Erik, Xu, Cong, Hamel, Ernest, Wagenbach, Michael, Kumasaka, Debra, Wageling, Nicholas B, Azorín, Daniel D, Winkler, Frank, Wordeman, Linda G, Holland, Eric C, Stella, Nephi
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Basic and Translational Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7813200/
https://ncbi.nlm.nih.gov/pubmed/33506204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/noajnl/vdaa165
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados