A brain-penetrant microtubule-targeting agent that disrupts hallmarks of glioma tumorigenesis

BACKGROUND: Glioma is sensitive to microtubule-targeting agents (MTAs), but most MTAs do not cross the blood brain barrier (BBB). To address this limitation, we developed the new chemical entity, ST-401, a brain-penetrant MTA. METHODS: Synthesis of ST-401. Measures of MT assembly and dynamics. Cell...

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Bibliographic Details
Published in:Neurooncol Adv
Main Authors: Horne, Eric A, Diaz, Philippe, Cimino, Patrick J, Jung, Erik, Xu, Cong, Hamel, Ernest, Wagenbach, Michael, Kumasaka, Debra, Wageling, Nicholas B, Azorín, Daniel D, Winkler, Frank, Wordeman, Linda G, Holland, Eric C, Stella, Nephi
Format: Artigo
Language:Inglês
Published: Oxford University Press 2020
Subjects:
Basic and Translational Investigations
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7813200/
https://ncbi.nlm.nih.gov/pubmed/33506204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/noajnl/vdaa165
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