A brain-penetrant microtubule-targeting agent that disrupts hallmarks of glioma tumorigenesis

BACKGROUND: Glioma is sensitive to microtubule-targeting agents (MTAs), but most MTAs do not cross the blood brain barrier (BBB). To address this limitation, we developed the new chemical entity, ST-401, a brain-penetrant MTA. METHODS: Synthesis of ST-401. Measures of MT assembly and dynamics. Cell...

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Bibliografski detalji
Izdano u:Neurooncol Adv
Glavni autori: Horne, Eric A, Diaz, Philippe, Cimino, Patrick J, Jung, Erik, Xu, Cong, Hamel, Ernest, Wagenbach, Michael, Kumasaka, Debra, Wageling, Nicholas B, Azorín, Daniel D, Winkler, Frank, Wordeman, Linda G, Holland, Eric C, Stella, Nephi
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2020
Teme:
Basic and Translational Investigations
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7813200/
https://ncbi.nlm.nih.gov/pubmed/33506204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/noajnl/vdaa165
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