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Selection of RNA aptamers against botulinum neurotoxin type A light chain through a non-radioactive approach

Botulinum neurotoxin (BoNT), a category A agent, is the most toxic molecule known to mankind. The endopeptidase activity of light chain domain of BoNT is the cause for the inhibition of the neurotransmitter release and the flaccid paralysis that leads to lethality in botulism. Currently, antidotes a...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Appl Biochem Biotechnol
Prif Awduron: Chang, Tzuu-Wang, Janardhanan, Pavithra, Mello, Charlene, Singh, Bal Ram, Cai, Shuowei
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2016
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5010959/
https://ncbi.nlm.nih.gov/pubmed/27085355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12010-016-2081-0
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