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Selection of RNA aptamers against botulinum neurotoxin type A light chain through a non-radioactive approach

Botulinum neurotoxin (BoNT), a category A agent, is the most toxic molecule known to mankind. The endopeptidase activity of light chain domain of BoNT is the cause for the inhibition of the neurotransmitter release and the flaccid paralysis that leads to lethality in botulism. Currently, antidotes a...

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Dades bibliogràfiques
Publicat a:Appl Biochem Biotechnol
Autors principals: Chang, Tzuu-Wang, Janardhanan, Pavithra, Mello, Charlene, Singh, Bal Ram, Cai, Shuowei
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5010959/
https://ncbi.nlm.nih.gov/pubmed/27085355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12010-016-2081-0
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