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Selection of RNA aptamers against botulinum neurotoxin type A light chain through a non-radioactive approach

Botulinum neurotoxin (BoNT), a category A agent, is the most toxic molecule known to mankind. The endopeptidase activity of light chain domain of BoNT is the cause for the inhibition of the neurotransmitter release and the flaccid paralysis that leads to lethality in botulism. Currently, antidotes a...

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Bibliografiset tiedot
Julkaisussa:Appl Biochem Biotechnol
Päätekijät: Chang, Tzuu-Wang, Janardhanan, Pavithra, Mello, Charlene, Singh, Bal Ram, Cai, Shuowei
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2016
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5010959/
https://ncbi.nlm.nih.gov/pubmed/27085355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12010-016-2081-0
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