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An analytical workflow for accurate variant discovery in highly divergent regions

BACKGROUND: Current variant discovery methods often start with the mapping of short reads to a reference genome; yet, their performance deteriorates in genomic regions where the reads are highly divergent from the reference sequence. This is particularly problematic for the human leukocyte antigen (...

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Detalhes bibliográficos
Publicado no:BMC Genomics
Main Authors: Tian, Shulan, Yan, Huihuang, Neuhauser, Claudia, Slager, Susan L.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5010666/
https://ncbi.nlm.nih.gov/pubmed/27590916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12864-016-3045-z
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