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An Integrated Human/Murine Transcriptome and Pathway Approach To Identify Prenatal Treatments For Down Syndrome

Anatomical and functional brain abnormalities begin during fetal life in Down syndrome (DS). We hypothesize that novel prenatal treatments can be identified by targeting signaling pathways that are consistently perturbed in cell types/tissues obtained from human fetuses with DS and mouse embryos. We...

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Pubblicato in:Sci Rep
Autori principali: Guedj, Faycal, Pennings, Jeroen LA, Massingham, Lauren J., Wick, Heather C., Siegel, Ashley E., Tantravahi, Umadevi, Bianchi, Diana W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5009456/
https://ncbi.nlm.nih.gov/pubmed/27586445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep32353
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