The Fetal Brain Transcriptome and Neonatal Behavioral Phenotype in the Ts1Cje Mouse Model of Down syndrome

Human fetuses with Down syndrome demonstrate abnormal brain growth and reduced neurogenesis. Despite the prenatal onset of the phenotype, most therapeutic trials have been conducted in adults. Here, we present evidence for fetal brain molecular and neonatal behavioral alterations in the Ts1Cje mouse...

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Pubblicato in:Am J Med Genet A
Autori principali: Guedj, Faycal, Pennings, Jeroen L. A., Ferres, Millie A., Graham, Leah C., Wick, Heather C., Miczek, Klaus A., Slonim, Donna K., Bianchi, Diana W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4844354/
https://ncbi.nlm.nih.gov/pubmed/25975229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ajmg.a.37156
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