Apigenin as a Candidate Prenatal Treatment for Trisomy 21: Effects in Human Amniocytes and the Ts1Cje Mouse Model

Human fetuses with trisomy 21 (T21) have atypical brain development that is apparent sonographically in the second trimester. We hypothesize that by analyzing and integrating dysregulated gene expression and pathways common to humans with Down syndrome (DS) and mouse models we can discover novel tar...

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Veröffentlicht in:Am J Hum Genet
Hauptverfasser: Guedj, Faycal, Siegel, Ashley E., Pennings, Jeroen L.A., Alsebaa, Fatimah, Massingham, Lauren J., Tantravahi, Umadevi, Bianchi, Diana W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7675036/
https://ncbi.nlm.nih.gov/pubmed/33098770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2020.10.001
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