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Apigenin as a Candidate Prenatal Treatment for Trisomy 21: Effects in Human Amniocytes and the Ts1Cje Mouse Model

Human fetuses with trisomy 21 (T21) have atypical brain development that is apparent sonographically in the second trimester. We hypothesize that by analyzing and integrating dysregulated gene expression and pathways common to humans with Down syndrome (DS) and mouse models we can discover novel tar...

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Опубликовано в: :Am J Hum Genet
Главные авторы: Guedj, Faycal, Siegel, Ashley E., Pennings, Jeroen L.A., Alsebaa, Fatimah, Massingham, Lauren J., Tantravahi, Umadevi, Bianchi, Diana W.
Формат: Artigo
Язык:Inglês
Опубликовано: Elsevier 2020
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7675036/
https://ncbi.nlm.nih.gov/pubmed/33098770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2020.10.001
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