Apigenin as a Candidate Prenatal Treatment for Trisomy 21: Effects in Human Amniocytes and the Ts1Cje Mouse Model

Human fetuses with trisomy 21 (T21) have atypical brain development that is apparent sonographically in the second trimester. We hypothesize that by analyzing and integrating dysregulated gene expression and pathways common to humans with Down syndrome (DS) and mouse models we can discover novel tar...

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Bibliographic Details
Published in:Am J Hum Genet
Main Authors: Guedj, Faycal, Siegel, Ashley E., Pennings, Jeroen L.A., Alsebaa, Fatimah, Massingham, Lauren J., Tantravahi, Umadevi, Bianchi, Diana W.
Format: Artigo
Language:Inglês
Published: Elsevier 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7675036/
https://ncbi.nlm.nih.gov/pubmed/33098770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2020.10.001
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