Leukotriene A4 hydrolase: abrogation of the peptidase activity by mutation of glutamic acid-296.

The metal-binding motif in the sequence of leukotriene A4 (LTA4) (EC 3.3.2.6), a bifunctional zinc metalloenzyme, contains a glutamic acid that is conserved in several zinc hydrolases. To study its role for the two catalytic activities, Glu-296 in mouse leukotriene A4 hydrolase was replaced by a glu...

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Bibliographic Details
Main Authors: Wetterholm, A, Medina, J F, Rådmark, O, Shapiro, R, Haeggström, J Z, Vallee, B L, Samuelsson, B
Format: Artigo
Language:Inglês
Published: 1992
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC50081/
https://ncbi.nlm.nih.gov/pubmed/1357660
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