Leukotriene A4 hydrolase: a critical role of glutamic acid-296 for the binding of bestatin.

Leukotriene A(4) hydrolase is a bifunctional Zn(2+)-containing enzyme catalysing the formation of the potent chemotaxin leukotriene B(4). From an analysis of three mutants of Glu-296 we have found that this catalytic residue is critical for the binding of bestatin, a classical aminopeptidase inhibit...

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Main Authors: Andberg, M, Wetterholm, A, Medina, J F, Haeggström, J Z
Format: Artigo
Sprog:Inglês
Udgivet: 2000
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1220797/
https://ncbi.nlm.nih.gov/pubmed/10642521
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