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Leukotriene A4 hydrolase: abrogation of the peptidase activity by mutation of glutamic acid-296.

The metal-binding motif in the sequence of leukotriene A4 (LTA4) (EC 3.3.2.6), a bifunctional zinc metalloenzyme, contains a glutamic acid that is conserved in several zinc hydrolases. To study its role for the two catalytic activities, Glu-296 in mouse leukotriene A4 hydrolase was replaced by a glu...

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Publicado no:Proc Natl Acad Sci U S A
Principais autores: Wetterholm, A, Medina, J F, Rådmark, O, Shapiro, R, Haeggström, J Z, Vallee, B L, Samuelsson, B
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1992
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC50081/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1357660/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.19.9141
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