Leukotriene A4 hydrolase: abrogation of the peptidase activity by mutation of glutamic acid-296.

The metal-binding motif in the sequence of leukotriene A4 (LTA4) (EC 3.3.2.6), a bifunctional zinc metalloenzyme, contains a glutamic acid that is conserved in several zinc hydrolases. To study its role for the two catalytic activities, Glu-296 in mouse leukotriene A4 hydrolase was replaced by a glu...

Full beskrivning

Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Wetterholm, A, Medina, J F, Rådmark, O, Shapiro, R, Haeggström, J Z, Vallee, B L, Samuelsson, B
Materialtyp: Artigo
Språk:Inglês
Publicerad: 1992
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC50081/
https://ncbi.nlm.nih.gov/pubmed/1357660
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk