Fragile X protein mitigates TDP-43 toxicity by remodeling RNA granules and restoring translation

RNA dysregulation is a newly recognized disease mechanism in amyotrophic lateral sclerosis (ALS). Here we identify Drosophila fragile X mental retardation protein (dFMRP) as a robust genetic modifier of TDP-43-dependent toxicity in a Drosophila model of ALS. We find that dFMRP overexpression (dFMRP...

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Publicado no:Hum Mol Genet
Main Authors: Coyne, Alyssa N., Yamada, Shizuka B., Siddegowda, Bhavani Bagevalu, Estes, Patricia S., Zaepfel, Benjamin L., Johannesmeyer, Jeffrey S., Lockwood, Donovan B., Pham, Linh T., Hart, Michael P., Cassel, Joel A., Freibaum, Brian, Boehringer, Ashley V., Taylor, J. Paul, Reitz, Allen B., Gitler, Aaron D., Zarnescu, Daniela C.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5007633/
https://ncbi.nlm.nih.gov/pubmed/26385636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddv389
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