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Wild-type and A315T mutant TDP-43 exert differential neurotoxicity in a Drosophila model of ALS

The RNA-binding protein TDP-43 has been linked to amyotrophic lateral sclerosis (ALS) both as a causative locus and as a marker of pathology. With several missense mutations being identified within TDP-43, efforts have been directed towards generating animal models of ALS in mouse, zebrafish, Drosop...

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Detalhes bibliográficos
Main Authors: Estes, Patricia S., Boehringer, Ashley, Zwick, Rebecca, Tang, Jonathan E., Grigsby, Brianna, Zarnescu, Daniela C.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3098735/
https://ncbi.nlm.nih.gov/pubmed/21441568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddr124
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