PPAR gamma activation is neuroprotective in a Drosophila model of ALS based on TDP-43

Amyotrophic Lateral Sclerosis (ALS) is a progressive neuromuscular disease for which there is no cure. We have previously developed a Drosophila model of ALS based on TDP-43 that recapitulates several aspects of disease pathophysiology. Using this model, we designed a drug screening strategy based o...

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Veröffentlicht in:Hum Mol Genet
Hauptverfasser: Joardar, Archi, Menzl, Judith, Podolsky, Taylor C., Manzo, Ernesto, Estes, Patricia S., Ashford, Sarah, Zarnescu, Daniela C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2015
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4381760/
https://ncbi.nlm.nih.gov/pubmed/25432537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddu587
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