An ALS-mutant TDP-43 neurotoxic peptide adopts an anti-parallel β-structure and induces TDP-43 redistribution

TDP-43 proteinopathies are clinically and genetically heterogeneous diseases that had been considered distinct from classical amyloid diseases. Here, we provide evidence for the structural similarity between TDP-43 peptides and other amyloid proteins. Atomic force microscopy and electron microscopy...

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Detalhes bibliográficos
Publicado no:Hum Mol Genet
Main Authors: Zhu, Li, Xu, Meng, Yang, Mengxue, Yang, Yanlian, Li, Yang, Deng, Jianwen, Ruan, Linhao, Liu, Jianghong, Du, Sidan, Liu, Xuehui, Feng, Wei, Fushimi, Kazuo, Bigio, Eileen H., Mesulam, Marsel, Wang, Chen, Wu, Jane Y.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4245047/
https://ncbi.nlm.nih.gov/pubmed/25113748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddu409
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