An ALS-associated mutation affecting TDP-43 enhances protein aggregation, fibril formation and neurotoxicity

Mutations in TARDBP, encoding TAR DNA-binding protein-43 (TDP-43), are associated with TDP-43 proteinopathies, including amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). We compared wild-type TDP-43 and an ALS-associated mutant TDP-43 in vitro and in vivo. The A315T...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Guo, Weirui, Chen, Yanbo, Zhou, Xiaohong, Kar, Amar, Ray, Payal, Chen, Xiaoping, Rao, Elizabeth J, Yang, Mengxue, Ye, Haihong, Zhu, Li, Liu, Jianghong, Xu, Meng, Yang, Yanlian, Wang, Chen, Zhang, David, Bigio, Eileen H, Mesulam, Marsel, Shen, Yan, Xu, Qi, Fushimi, Kazuo, Wu, Jane Y
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3357956/
https://ncbi.nlm.nih.gov/pubmed/21666678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2053
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky