Endocytosis regulates TDP-43 toxicity and turnover

Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron degenerative disease. ALS-affected motor neurons exhibit aberrant localization of a nuclear RNA binding protein, TDP-43, into cytoplasmic aggregates, which contributes to pathology via unclear mechanisms. Here, we demonstrate that TDP-43 tu...

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Udgivet i:Nat Commun
Main Authors: Liu, Guangbo, Coyne, Alyssa N., Pei, Fen, Vaughan, Spencer, Chaung, Matthew, Zarnescu, Daniela C., Buchan, J. Ross
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5727062/
https://ncbi.nlm.nih.gov/pubmed/29233983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02017-x
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