Učitavanje...
PABPN1 suppresses TDP-43 toxicity in ALS disease models
TAR DNA-binding protein 43 (TDP-43) is a major disease protein in amyotrophic lateral sclerosis (ALS) and related neurodegenerative diseases. Both the cytoplasmic accumulation of toxic ubiquitinated and hyperphosphorylated TDP-43 fragments and the loss of normal TDP-43 from the nucleus may contribut...
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| Izdano u: | Hum Mol Genet |
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| Glavni autori: | , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Oxford University Press
2015
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4550816/ https://ncbi.nlm.nih.gov/pubmed/26130692 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddv238 |
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