PABPN1 suppresses TDP-43 toxicity in ALS disease models

TAR DNA-binding protein 43 (TDP-43) is a major disease protein in amyotrophic lateral sclerosis (ALS) and related neurodegenerative diseases. Both the cytoplasmic accumulation of toxic ubiquitinated and hyperphosphorylated TDP-43 fragments and the loss of normal TDP-43 from the nucleus may contribut...

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Publicat a:Hum Mol Genet
Autors principals: Chou, Ching-Chieh, Alexeeva, Olga M., Yamada, Shizuka, Pribadi, Amy, Zhang, Yi, Mo, Bi, Williams, Kathryn R., Zarnescu, Daniela C., Rossoll, Wilfried
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2015
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4550816/
https://ncbi.nlm.nih.gov/pubmed/26130692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddv238
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