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Respiration enhances TDP-43 toxicity, but TDP-43 retains some toxicity in the absence of respiration
The trans-activating response DNA-binding protein 43 (TDP-43) is a transcriptional repressor and splicing factor. TDP-43 is normally mostly in the nucleus, although it shuttles to the cytoplasm. Mutations in TDP-43 are one cause of familial amyotrophic lateral sclerosis (ALS). In neurons of these pa...
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| Publicado no: | J Mol Biol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6502655/ https://ncbi.nlm.nih.gov/pubmed/30905713 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2019.03.014 |
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